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Lupus, Vol. 12, No. 2, 79-85 (2003)
DOI: 10.1191/0961203303lu321oa

DNA methylation in systemic lupus erythematosus

I Sekigawa

Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan, sekigawa{at}mtd.biglobe.ne.jp

M Okada

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Ogasawara

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Kaneko

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

T Hishikawa

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Hashimoto

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, seem likely to contribute to elucidation of the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), although the relationship between DNA methylation and SLE has long been the subject of investigation.To obtain a deeper understandingof the role of DNA methylation in the induction of SLE, we reviewed the relationship between DNA methylation and SLE based on findings reported in the literature and our own data. Various studies, including ours, have indicated the possible importance of DNA methylation, especially hypomethylation, in the etiology of SLE. These epigenetic studies may give us clues towards elucidation of the pathogenesis of SLE and development of new therapeutic strategies for this disease.

Key Words: systemic lupus erythematosus • methylation • CpG motif • DNA methyltransferase • human endogenous retroviruses


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