This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sekigawa, I Articles by Hashimoto, H Search for Related Content PubMed PubMed Citation Articles by Sekigawa, I Articles by Hashimoto, H Social Bookmarking                         What's this?

DNA methylation in systemic lupus erythematosus

Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan, sekigawa{at}mtd.biglobe.ne.jp

M Okada

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Ogasawara

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Kaneko

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

T Hishikawa

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Hashimoto

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, seem likely to contribute to elucidation of the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), although the relationship between DNA methylation and SLE has long been the subject of investigation.To obtain a deeper understandingof the role of DNA methylation in the induction of SLE, we reviewed the relationship between DNA methylation and SLE based on findings reported in the literature and our own data. Various studies, including ours, have indicated the possible importance of DNA methylation, especially hypomethylation, in the etiology of SLE. These epigenetic studies may give us clues towards elucidation of the pathogenesis of SLE and development of new therapeutic strategies for this disease.

Key Words: systemic lupus erythematosus • methylation • CpG motif • DNA methyltransferase • human endogenous retroviruses

Lupus, Vol. 12, No. 2, 79-85 (2003)
DOI: 10.1191/0961203303lu321oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. Wang, M Zhang, X. Li, H Zhang, W Chen, M Kan, and Y. Wang Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation Lupus, October 1, 2009; 18(12): 1037 - 1044. [Abstract] [PDF]

				S. Nakano, S. Morimoto, J. Suzuki, K. Nozawa, H. Amano, Y. Tokano, and Y. Takasaki Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus Rheumatology, February 1, 2008; 47(2): 145 - 149. [Abstract] [Full Text] [PDF]

				D. Rodenhiser and M. Mann Epigenetics and human disease: translating basic biology into clinical applications Can. Med. Assoc. J., January 31, 2006; 174(3): 341 - 348. [Abstract] [Full Text] [PDF]

				I Sekigawa, T Naito, K Hira, K Mitsuishi, H Ogasawara, H Hashimoto, and H Ogawa Possible mechanisms of gender bias in SLE: a new hypothesis involving a comparison of SLE with atopy Lupus, April 1, 2004; 13(4): 217 - 222. [Abstract] [PDF]