This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kolar, G R Articles by Capra, J D Search for Related Content PubMed PubMed Citation Articles by Kolar, G R Articles by Capra, J D Social Bookmarking                         What's this?

The NOD/SCID chimeric mouse model of human B cell development: studies on the VH4 family immunoglobulin repertoire and implications for SLE

Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, grant-kolar{at}omrf.ouhsc.edu

J D Capra

Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

The use of the NOD=SCID mouse as a transplant recipient for human cord blood B cell progenitorsas a tool for investigations into the development of human B cells has become an exciting reality. The characteristics of the immunoglobulin repertoire in such a model is important to investigate, as it is possiblethat normal or skewed representationscould be produced.Here we reviewour current work in which we describe a normal VH4 repertoire produced in this chimeric mouse model and describe the differences in combinatorial diversity between the human cells that were isolated from the bone marrow and spleen. The implications of this model for studies of systemic lupus erythematosus are also discussed.

Key Words: NOD/SCID mice • cord blood • immunoglobulinrepertoire • systemic lupus erythematosus

Lupus, Vol. 12, No. 3, 158-162 (2003)
DOI: 10.1191/0961203303lu348xx


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?