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Autoantibodies and glomerulonephritis in systemic lupus erythematosus

University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, and Departments of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA, sf2e{at}virginia.edu

J D Castillo

University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, and Departments of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA

U S Deshmukh

University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, and Departments of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA

J E Lewis

University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, and Departments of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA

S T Waters

University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, and Departments of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA

F Gaskin

Psychiatric Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA

Autoantibody diversification to a variety of autoantigens is a hallmark for systemic autoimmunity.SLE representsa prototype.In this article the roots of the important questions probed by the Kunkel laboratory in SLE research are traced. Data from the recent animal work by the laboratory of Shu Man Fu are summarized to emphasize the importance of further exploration of autoantibody specificities in lupus with a special emphasis on nephritis and to suggest a broader perspective regarding lupus autoantibody reactivities in addition to those against nuclear components.

Key Words: systemic lupus erythematosus • autoantibodies • glomerulonephritis • anti-dsDNA • SnRNP • Ro/La

Lupus, Vol. 12, No. 3, 175-180 (2003)
DOI: 10.1191/0961203303lu352xx


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