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Why the lupus problem remains unsolved and I am a human geneticist

Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA, jlg2003{at}med.cornell.edu

A personal account is given: 1) of my early work with lupus erythematosus including the first observation of formation of the LE cell and the experimental production in animal renal glomeruli of hematoxyphil bodies, the pathognomonic lesion of lupus; and, 2) of how discontinuationof work on lupus - by decree - diverted my life in science away from immunology into another area of human genetics, namely cytogenetics, the discovery of genetically determined genomic instability and the choice of Bloom’s syndrome as an investigational model for human cancer.

Key Words: autoimmunity • Bloom’s syndrome • hematoxyphil body • LE cell • somatic crossing-over

Lupus, Vol. 12, No. 3, 181-189 (2003)
DOI: 10.1191/0961203303lu353xx


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