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A fatal case of systemic lupus erythematosus complicated by acute pancreatitis, invasive aspergillosis and features of thrombotic thrombocytopenic purpuraDepartment of Rheumatology, University of Milan and Gaetano Pini Institute, Milano, Italy
Pediatric Department, ICP, Milano, Italy, rolando.cimaz{at}unimi.it We describe the case of a 23-year-oldwoman with a mild form of systemic lupus erythematosus who presented a febrile illness rapidly followed by general worsening, neurologic involvement, renal failure and coma. While hospitalized in the intensive care unit she also suffered from acute pancreatitis, microangiopathic hemolitic anemia, thrombocytopenia and prolongation of clotting times. Despite aggressive treatment the patient died at day 17 of hospitalization in the intensive care unit. At autopsy necrotico-hemorragicpancreatitis, diffuse pneumonia, peritonitis and cerebral edema were present. Most striking was the presence of invasive aspergillosis, which was detected in all organs examined. In this case thrombotic thrombocytopenic purpura, invasive aspergillosis and multiorgan failure including acute pancreatitis were present. The relationship between the three entities is complex, and it is difficult to establish which of the different events took place first and triggered the others.
Key Words: aspergillosis • pancreatitis • SLE • thrombotic thrombocytopenicpurpura
Lupus, Vol. 12, No. 5,
418-421 (2003) |
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