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Lupus
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Effects of liposteroid on the hemophagocytic syndrome in systemic lupus erythematosus

M Funauchi

Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Japan, funauchi{at}med.kindai.ac.jp

M Ohno

Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Japan

T Yamagata

Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Japan

Y Nozaki

Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Japan

K Kinoshita

Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Japan

A Kanamaru

Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Japan

Hemophagocytic syndrome (HPS) is a life-threatening disorder characterized by pancytopenia and activation of macrophages. Recently, corticosteroid incorporated in lipid microspheres (liposteroid) has been reported to be taken up by macrophages and to suppress their functions. Here we present a case of systemic lupus erythematosus complicated by HPS that was successfully treated with liposteroid in addition to an oral corticosteroidand intravenoushigh-dose cyclophosphamidetherapy. The serum levels of tumor necrosis factor-a and ferritin that have been reported to be associated with activity of macrophages remarkably reduced after liposteroid administration. This case suggests that liposteroid is useful for the treatment of HPS.

Key Words: hemophagocytic syndrome • liposteroid • macrophage • pancytopenia

Lupus, Vol. 12, No. 6, 483-485 (2003)
DOI: 10.1191/0961203303lu373oa
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