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HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus

UO Complessa di Reumatologia, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy, gsebastiani{at}scamilloforlanini.rm.it

M Galeazzi

Istituto di Reumatologia, Universita di Siena, Siena, Italy

A Tincani

Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy

R Scorza

Istituto di Medicina Interna, Malattie Infettive e Immunopatologia, Universita di Milano, Milano, Italy

A Mathieu

II Cattedra di Reumatologia, Universita di Cagliari, Cagliari, Italy

G Passiu

II Cattedra di Reumatologia, Universita di Cagliari, Cagliari, Italy

G Morozzi

Istituto di Reumatologia, Universita di Siena, Siena, Italy

J C Piette

Service Medecine Interne, CHU Pitie-Salpetriere, Paris, France

R Cervera

Unitat de Malalties Autoimmunes Sistemiques, Hospital Clinic, Barcelona, Spain

F Houssiau

Service du Rhumatologie, Universite Catholique de Louvain, Bruxelles, Belgium

J Smolen

Department of Medicine, Lainz Hospital, Vienna, Austria

A Fernandez Nebro

Hospital and University of Malaga, Malaga, Spain

E De Ramon

Hospital and University of Malaga, Malaga, Spain

A Jedryka Goral

Institute of Rheumatology, Warsaw, Poland

C Papasteriades

Evangelismos Hospital, Athens, Greece

G B Ferrara

Centro Biotecnologie Avanzate, Genova, Italy

C Carcassi

Dipartimento Genetica Medica, Universitàdi Cagliari, Cagliari, Italy

F Bellisai

Istituto di Reumatologia, Universita di Siena, Siena, Italy

R Marcolongo

Istituto di Reumatologia, Universita di Siena, Siena, Italy

European Concerted Action on Immunogenetics of SLE

Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta₂ GPI (aß₂ GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus(SLE). We studied 577 European patients with SLE. aCL and aß₂ GPI antibodies were measured by ELISA. Molecular typing of HLA-DPB1 locus was performed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. aCL showed positive association with -DPB1*1501 (P 0.005, OR 7.4), and -DPB1*2301 (P 0.009, OR 3.3). aß₂ GPI showed positive association with -DPB1*0301 (P 0.01, OR 1.9), and -DPB1*1901 (P 0.004, OR 8.1). In addition, livedo reticularis was associated with -DPB1*1401, and Raynaud’s phenomenon with -DPB1*2001. In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE.

Key Words: anti-ß2 GPI antibodies • anticardiolipin antibodies • antiphospholipid syndrome • HLA • HLA-DPB1 locus • systemic lupus erythematosus

Lupus, Vol. 12, No. 7, 560-563 (2003)
DOI: 10.1191/0961203303lu402oa


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