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Mycophenolate mofetil as a treatment for autoimmune haemolytic anaemia in patients with systemic lupus erythematosus and antiphospholipid syndrome

The Lupus Unit, Guy’s and St Thomas’ Trust, London, UK

M Y Karim

Department of Immunology, Guy’s and St Thomas’ Trust, London, UK

B J Hunt

The Lupus Unit, Guy’s and St Thomas’ Trust, London, UK, Department of Haematology, Guy’s and St Thomas’ Trust, London, UK

Unresponsive autoimmune haemolytic anaemia (AIHA) may require therapy with second-line drugs. There is no consensusthat any one of these agents is more effectivethan another. Mycophenolatemofetil (MMF) is an immunosuppressivedrug proven to be effectivein reducing renal allograftrejectionas well as being used in autoimmune diseases including systemic lupus erythematosus (SLE). We describe its use in two patients who were treated with MMF for AIHA in the context of underlying SLE and antiphospholipid syndrome (APS). The patients showed a good response to treatment with MMF, suggesting a possible role in the treatment of AIHA.

Key Words: autoimmune haemolytic anaemia • lupus • mycophenolate mofetil

Lupus, Vol. 12, No. 8, 633-635 (2003)
DOI: 10.1191/0961203303lu419cr


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