Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sen, D
Right arrow Articles by Isenberg, D. A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sen, D
Right arrow Articles by Isenberg, D. A
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 12, No. 9, 651-658 (2003)
DOI: 10.1191/0961203303lu456rr

Antineutrophil cytoplasmic autoantibodies in systemic lupus erythematosus

D Sen

Centre for Rheumatology, University College London, London, UK, debajitsen{at}doctors.org.uk

David A Isenberg

Centre for Rheumatology, University College London, London, UK

Although antineutrophil cytoplasmic antibodies (ANCA) were first associated with the primary vasculitides, it is now clear that 15-20% of patients with lupus have detectable ANCA. In this short review we confirm that the major link is with perinuclear ANCA (pANCA) but not cytoplasmic ANCA (cANCA). ANCA to myeloperoxidaseare associatedwith drug-inducedlupus.There may be a link between pANCA levels and disease activity in some patients although the links to specific organ involvement are not proven. ANCA in lupus must be interpreted cautiously with particular attention paid to laboratorytechnique, the size, age and genetic backgroundof the populationsstudied.

Key Words: antineutrophil cytoplasmic antibodies • systemic lupus erythematosus


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 CJASNHome page
S. H. Nasr, V. D. D'Agati, H.-R. Park, P. L. Sterman, J. D. Goyzueta, R. M. Dressler, S. M. Hazlett, R. N. Pursell, C. Caputo, and G. S. Markowitz
Necrotizing and Crescentic Lupus Nephritis with Antineutrophil Cytoplasmic Antibody Seropositivity
Clin. J. Am. Soc. Nephrol., May 1, 2008; 3(3): 682 - 690.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
G Fuentes-Paez, J Celis-Sanchez, J Torres, H Martinez-Osorio, and J M Herreras
Letter to the Editor
Lupus, November 1, 2005; 14(11): 928 - 929.
[PDF]

Home page
 LupusHome page
J D Reveille
Predictive value of autoantibodies for activity of systemic lupus erythematosus
Lupus, May 1, 2004; 13(5): 290 - 297.
[Abstract] [PDF]