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Lupus
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Antineutrophil cytoplasmic autoantibodies in systemic lupus erythematosus

D Sen

Centre for Rheumatology, University College London, London, UK, debajitsen{at}doctors.org.uk

David A Isenberg

Centre for Rheumatology, University College London, London, UK

Although antineutrophil cytoplasmic antibodies (ANCA) were first associated with the primary vasculitides, it is now clear that 15-20% of patients with lupus have detectable ANCA. In this short review we confirm that the major link is with perinuclear ANCA (pANCA) but not cytoplasmic ANCA (cANCA). ANCA to myeloperoxidaseare associatedwith drug-inducedlupus.There may be a link between pANCA levels and disease activity in some patients although the links to specific organ involvement are not proven. ANCA in lupus must be interpreted cautiously with particular attention paid to laboratorytechnique, the size, age and genetic backgroundof the populationsstudied.

Key Words: antineutrophil cytoplasmic antibodies • systemic lupus erythematosus

Lupus, Vol. 12, No. 9, 651-658 (2003)
DOI: 10.1191/0961203303lu456rr
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