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Fcreceptor II polymorphism in Vietnamese patients with systemic lupus erythematosus

Department of Microbiology and Immunology, Aichi Medical University, Nagakute, Aichi 480-1195, Japan

T Sugiyama

Department of Microbiology and Immunology, Aichi Medical University, Nagakute, Aichi 480-1195, Japan

T Yokochi

Department of Microbiology and Immunology, Aichi Medical University, Nagakute, Aichi 480-1195, Japan, yokochi{at}aichi-med-u.ac.jp

The polymorphism of the Fc receptor for IgG class IIA (FcgRIIA) in Vietnamese patients with systemic lupus erythematosus (SLE) was examined by using the polymerase chain reaction (PCR) method with genomic DNA and allele-specific primers. In the frequency of FcgRIIA genotypes, the homozygosity of FcgRIIA-H131 was four (8.3%) of 48 SLE patients and 16 (37.2%) of 43 healthy controls (P < 0.01). The allele frequency of FcgRIIA-H131 in SLE patients was also significantly lower than that in the controls (P < 0.05). The unusual distribution of FcgRIIA polymorphism suggested that FcgRIIA might be involved in the development of SLE in Vietnamese patients.

Key Words: FcgRIIA • SLE • Vietnamese

Lupus, Vol. 12, No. 9, 704-706 (2003)
DOI: 10.1191/0961203303lu454sr


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