This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Huang, C-M Articles by Tsai, F-J Search for Related Content PubMed PubMed Citation Articles by Huang, C-M Articles by Tsai, F-J Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Medline Plus Health Information Lupus Social Bookmarking                   What's this?

Epidermal growth factor receptor (EGFR) gene Bsr I polymorphism is associated with systemic lupus erythematosus

Department of Internal Medicine, Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan

C-H Tsai

Taichung Healthcare and Management University, Taiwan, d0704{at}www.cmuh.org.tw

C-L Chen

Foo Yin Institute of Technology, Kaohsiung, Taiwan

C-P Chang

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

C-C Lai

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

F-J Tsai

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, College of Chinese Medicine, China Medical University, Taiwan

The purpose of this study was to determine if epidermal growth factor receptor (EGFR) gene polymorphism was a marker of susceptibility to or severity of Chinese patients with systemic lupus erythematosus (SLE) in Taiwan. The study included 119 Chinese patients with SLE. One hundred unrelated healthy individuals living in central Taiwan served as control subjects. Polymorphisms of the EGFR Bsr I gene were typed from genomic DNA. The genotypes, allelic frequencies and carriage rates were compared between SLE patients and control subjects. The relationship between allelic frequencies and clinical manifestations of SLE was evaluated. For the genotype of EGFR gene Bsr I polymorphism, there was statistically significant differences between the SLE and control groups (chi-squared test, P = 0.009, ²= 9.21). In addition, there was significant association between the two groups in allelic frequency of the T allele (P = 0.02, ²= 5.27). However, we did not detect any association between EGFR genotype and clinical or laboratory profiles in SLE patients. The results suggest that the EGFR gene Bsr I polymorphism is related to SLE.

Key Words: epidermal growth factor receptor (EGFR) • systemic lupus erythematosus (SLE)

Lupus, Vol. 13, No. 10, 773-776 (2004)
DOI: 10.1191/0961203304lu1081oa


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H Doi, T Matsushita, N Isobe, T Matsuoka, M Minohara, H Ochi, and J. Kira Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody Multiple Sclerosis, March 1, 2009; 15(3): 304 - 310. [Abstract] [PDF]

				K. Kitao, S. Yoshida, S. Kennedy, N. Takemura, M. Sugimoto, M. Deguchi, N. Ohara, and T. Maruo Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 Gene Polymorphisms in Endometrial Cancer in a Japanese Population Reproductive Sciences, May 1, 2007; 14(4): 349 - 357. [Abstract] [PDF]