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Autoantibodies recognizing the 27 carboxy-terminal amino acids of calpastatin are associated with secondary Sjögren syndrome in systemic lupus erythematosus

Inserm U519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides (IFR 23), FacultédeMédecine et de Pharmacie, Rouen, France, Service de Médecine Interne, Centre Hospitalier Universitaire d’Amiens, France, salle.valery{at}chu-amiens.fr

O Vittecoq

Inserm U519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides (IFR 23), FacultédeMédecine et de Pharmacie, Rouen, France, Service de Rhumatologie, Centre Hospitalier Universitaire de Rouen, France

F Jouen-Beades

Inserm U519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides (IFR 23), FacultédeMédecine et de Pharmacie, Rouen, France

J F Ménard

Unité de Biométrie-Biostatistique, Centre Hospitalier Universitaire de Rouen, France

J P Ducroix

Service de Médecine Interne, Centre Hospitalier Universitaire d’Amiens, France

M Godin

Service de Néphrologie, Centre Hospitalier Universitaire de Rouen, France

X Le Loët

Inserm U519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides (IFR 23), FacultédeMédecine et de Pharmacie, Rouen, France, Service de Rhumatologie, Centre Hospitalier Universitaire de Rouen, France

F Tron

Inserm U519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides (IFR 23), FacultédeMédecine et de Pharmacie, Rouen, France

The objective of this study was to determine in systemic lupus erythematosus (SLE) the prevalence and clinical significance of anticalpastatin antibodies (ACAST), an autoantibody population previously detected in sera from patients with various connective tissue diseases. Eighty-four patients with SLE (mean age: 30 years at diagnosis, females 77) that fulfilled ACR criteria were included in the study retrospectively. Several clinical and biological data were collected. ACAST were detected by a solid-phase enzyme linked immunosorbent assay (ELISA) using as antigen a synthetic peptide corresponding to the 27 C-terminal amino acids of calpastatin (CAST-C27). The prevalence of ACAST-C27 was 13% (11/84) in SLE patients. No correlation was found between the presence of ACAST-C27 and clinical manifestations such as thrombosis and vasculitis. Furthermore, no correlation was observed with the presence of antiphospholipid antibodies (APL). However, we found a statistically significant association between the presence of ACAST-C27 and that of secondary Sjögren syndrome (P = 0.01). The conclusion is ACAST-C27 are not associated with thrombosis in SLE patients. The association observed between ACAST-C27 and secondary Sjögren syndrome suggests that ACAST-C27 might be useful in discriminating a clinical subgroup of SLE patients.

Key Words: anti-calpastatin antibodies • Sjögren syndrome • systemic lupus erythematosus

Lupus, Vol. 13, No. 10, 800-804 (2004)
DOI: 10.1191/0961203303lu2017oa


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