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Familial antiphospholipid antibodies and acquired circulating anticoagulants

Department of Internal Medicine, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon

I Uthman

Division of Rheumatology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon

A Chahel

Division of Hematology/Oncology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon

F Khoury

Department of Internal Medicine, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon

T Arayssi

Division of Rheumatology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon

A Taher

Division of Hematology/Oncology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon ataher{at}aub.edu.lb, ali.taher{at}aub.edu.lb

Familial clustering of elevated antiphospholipid antibody levels has been described, but the reports are heterogeneous with regard to the characterization of the antiphospholipid syndrome (APS), coexisting autoimmune diseases and clinical implications. We report a familial occurrence of APS in two patients, in the presence of SLE in the mother and absence of autoimmune diseases in the daughter along with acquired circulating inhibitors in both cases: platelet inhibitor and factor IX inhibitor, respectively.

Key Words: factor IX inhibitor • familial antiphospholipid syndrome • platelet inhibitor • prolonged bleeding time

Lupus, Vol. 13, No. 10, 812-814 (2004)
DOI: 10.1191/0961203303lu1059cr


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