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Lupus
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ACR classification criteria for systemic lupus erythematosus: complement components

O Nived

Department of Rheumatology, University Hospital, Sweden

G Sturfelt

Department of Rheumatology, University Hospital, Sweden, gunnar.sturfelt{at}reum.lu.se

Complement is involved in the pathogenesis of systemic lupus erythematosus (SLE) and has also a seemingly paradoxical protective role in the development of the disease. Low levels of components within the classical pathway of complement especially C1q, C4 and C3 have a high specificity for SLE diagnosis and should be considered as promising for inclusion in classification criteria of SLE.

Key Words: C1q • C3 • C4 • complement • SLE • SLE classification criteria

Lupus, Vol. 13, No. 11, 877-879 (2004)
DOI: 10.1191/0961203304lu2027oa


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