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Effects of fludarabine treatment on murine lupus nephritis

Department of Pediatrics, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA, oyjones{at}cnmc.orgxs

P J Alexander

Department of Pediatrics, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

A Lacson

Laboratory and Pathology Medicine, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

F Gok

GATA Medical Faculty, Division of Pediatric Nephrology and Rheumatology, 06018 Etlik, Ankara, Turkey

A Feliz

Department of Surgery, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

Y Marikar

Department of Pediatrics, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

C Madivi

Department of Pediatrics, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

J M Jones

Department of Pediatrics, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

R A Good

Department of Pediatrics, University of South Florida All Children’s Hospital, 801 Sixth Street South, St Petersburg, Florida 33701, USA

BXSB mice, a murine model of systemic lupus erythematosus (SLE), were treated with two different doses of fludarabine for a four-week period and examined two weeks after the final dose. Control mice were treated with saline or cyclophosphamide. Mice treated with fludarabine had a significant reduction in renal pathology compared to control mice. Fludarabine-treated mice also had an almost 10-fold increase in percentile of CD8+CD25+ T cells in the spleen and a smaller but significant increase in CD4+CD25+ cells. Mice treated with cyclophosphamide had a greater leucopenia compared to the other groups and a significant reduction in percentile of B220+ cells in peripheral blood and spleen. Serum autoantibody levels to dsDNA did not differ significantly among the groups, but were higher in 4/10 mice treated with fludarabine. Although few trials of fludarabine for human SLE have been conducted, additional studies may be warranted.

Key Words: cyclophosphamide • fludarabine • lupus • mouse • nephritis

Lupus, Vol. 13, No. 12, 912-916 (2004)
DOI: 10.1191/0961203304lu2032oa


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