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Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, hnakashi{at}intmed1.med.kyushu-u.ac.jp

M Akahoshi

Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN Yokohama Institute, Yokohama, Japan

S Shimizu

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Y Inoue

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

K Miyake

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

I Ninomiya

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

T Igawa

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

A Sadanaga

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

T Otsuka

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

M Harada

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Lupus nephritis presents two polar histological patterns, diffuse proliferative glomerulonephritis (DPGN) and membranous glomerulonephritis (MGN). In the kidney tissue of DPGN, numerous mononuclearcells were seen in the interstitium and glomeruli; on the other hand in MGN, infiltrating cells were less frequent. Monocyte chemoattractantprotein-1 (MCP-1) is a potent chemoattractantfor monocytes, T-cells, and natural killer cells. In this study we assessed the significance of the MCP-1 gene in determination of the histological phenotype in lupus nephritis. There was no association between the risk of DPGN and the MCP-1 gene genotype.

Key Words: gene polymorphism • membranous glomerulonephritis (WHO class V) • MCP-1 • proliferative glomerulonephritis (WHO class IV) • SLE

Lupus, Vol. 13, No. 3, 165-167 (2004)
DOI: 10.1191/0961203304lu523oa


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