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Antinucleosome antibodies may help predict development of systemic lupus erythematosus in patients with primary antiphospholipid syndrome

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

J Rojas-Serrano

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

J Cabiedes

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

J Alcocer-Varela

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, jorgeav{at}servidor.unam.mx

Patients with primary antiphospholipid syndrome (PAPS) may evolve to systemic lupus erythematosus (SLE), even many years later. This makes differentiation between primary and secondary antiphospholipidsyndrome a difficult task. Studies in murine models of lupus have shown that the developmentof antinucleosome(anti-NCS) antibodiesmay occur from the early stages of life. We therefore hypothesizethat anti-NCS antibodies could help predict developmentof SLE in patients with PAPS. We studied anti-NCS antibodies in 18 PAPS patients (15 female, three male), followed for a mean of 11 years to evaluate the potential development of SLE. When PAPS was diagnosed, nine patients were positive for anti-NCS antibodies. Six of them developed clinical manifestationsof SLE. In contrast, none of the patients who were negative to anti-NCS antibodies developed it. These findings suggest that anti-NCS antibodiescould help predict which patients with PAPS may eventually develop SLE.

Key Words: antinucleosome antibodies • primary antiphospholipid syndrome • systemic lupus erythematosus

Lupus, Vol. 13, No. 3, 177-181 (2004)
DOI: 10.1191/0961203304lu526oa


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