SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Sekigawa, I
Right arrow Articles by Ogawa, H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sekigawa, I
Right arrow Articles by Ogawa, H
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Possible mechanisms of gender bias in SLE: a new hypothesis involving a comparison of SLE with atopy

I Sekigawa

Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan, isekigawa{at}mva.biglobe.ne.jp

T Naito

Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan

K Hira

Department of Dermatology and Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan

K Mitsuishi

Department of Dermatology and Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan

H Ogasawara

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Hashimoto

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Ogawa

Department of Dermatology and Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan

The prevalence of systemic lupus erythematosus (SLE) is far higher in females than in males, and numerous investigations of this gender bias have been performed from several perspectives. Sex hormones, particularly estrogens, may be significant in causing the gender discrepancy. This article discusses the possible importance of estrogens in regulating the expression of and responsivity to autoantigens in SLE and in atopic disorders, which are associated with hyperreactivity to exogenous antigens. Estrogens seem to play an important role in the overexpressionof endogenousautoantigens, such as human endogenousretroviruses (HERV), and this may be related to the existence of a gender bias in the incidence of SLE but not atopy.

Key Words: atopic disease • DNA methylation • estrogen • human endogenous retrovirus • systemic lupus erythematosus

Lupus, Vol. 13, No. 4, 217-222 (2004)
DOI: 10.1191/0961203304lu1012ed
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
F. Wang, S. M. Roberts, E. J. Butfiloski, L. Morel, and E. S. Sobel
Acceleration of Autoimmunity by Organochlorine Pesticides: A Comparison of Splenic B-Cell Effects of Chlordecone and Estradiol in (NZBxNZW)F1 Mice
Toxicol. Sci., September 1, 2007; 99(1): 141 - 152.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
G. Riemekasten and B. H. Hahn
Key autoantigens in SLE
Rheumatology, August 1, 2005; 44(8): 975 - 982.
[Full Text] [PDF]


Advertisement