Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tlacuilo-Parra, J A
Right arrow Articles by Salazar-Páramo, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tlacuilo-Parra, J A
Right arrow Articles by Salazar-Páramo, M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 13, No. 4, 270-273 (2004)
DOI: 10.1191/0961203304lu1013cr

Acquired ichthyosis associated with systemic lupus erythematosus

J A Tlacuilo-Parra

Medical Research Unit in Clinical Epidemiology, Hospital de Especialidades Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara and Universities of Colima and Guadalajara, México, albtlacuilo{at}yahoo.com

E Guevara-Gutiérrez

Dermatology Department, Instituto Dermatológico de Jalisco, Secretaria de Salud Jalisco, Guadalajara, México

M Salazar-Páramo

Medical Research Unit in Clinical Epidemiology, Hospital de Especialidades Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara and Universities of Colima and Guadalajara, México

Acquired ichthyosis is an uncommon disease, it is characterized by symmetric scaling of the skin, which ranges from minor roughness and dryness to the desquamation of large plaques. It has been associated with various systemic diseases, although malignant conditions, especially Hodgkin’s lymphoma are the most commonly cited. Drugs, HIV infection and autoimmune diseases such as dermatomyositis and mixed connective tissue disease have also been associated, and it has only rarely been found among patients with systemic lupus erythematosus (SLE). Herein, we report a patient with active SLE who developed a generalized acquired ichthyosis corroborated with skin biopsy, which completely disappearedafter treatment. The associationof autoimmune conditionswith acquired ichthyosis could indicate that an abnormal host immune response, probably against components of the granular cell layer in particular the keratohyalin granules, may have a role in the pathogenesis. Thus, this finding may be a relevant cutaneous marker for an autoimmune origin.

Key Words: acquired ichthyosis • granular layer • keratohyalin • profilaggrin • systemic lupus erythematosus


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?