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Lupus, Vol. 13, No. 5, 312-316 (2004)
DOI: 10.1191/0961203304lu1018oa

Does B cell depletion have a role to play in the treatment of systemic lupus erythematosus?

C Gorman

Centre for Rheumatology, The Middlesex Hospital, University College London, UK

M Leandro

Centre for Rheumatology, The Middlesex Hospital, University College London, UK

D Isenberg

Centre for Rheumatology, The Middlesex Hospital, University College London, UK, d.isenberg{at}ud.ac.uk

B cell dysfunctionand pathogenicautoantibodyformationare thoughtto be criticalin the pathogenesis of systemic lupus erythematosus (SLE). In this review we will summarize the results of attempts to utilize B cell depletion, based on the use of a chimeric monoclonalantibody(MAb) specific for human CD20, rituximab, for the treatment of patients with SLE.

Key Words: anti-CD20 • rituximab • systemic lupus erythematosus


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