This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Schmidt, K N Articles by Ouyang, W Search for Related Content PubMed PubMed Citation Articles by Schmidt, K N Articles by Ouyang, W Social Bookmarking                         What's this?

Targeting interferon-: a promising approach for systemic lupus erythematosus therapy

Department of Immunology, Genentech Inc., San Francisco, USA, kerstin{at}gene.com

W Ouyang

Department of Immunology, Genentech Inc., San Francisco, USA

System lupus erythematosus (SLE) is an autoimmune disease with multicellular pathogeneic components.Recent studiessuggestan importantrole for interferon-a (IFN) in the immunopathogenesis of SLE. Data demonstrating a correlationbetween IFN-a and SLE disease severity range from elevated IFN-a levels in patients’serum and induction of IFN-regulated genes in peripheral blood mononuclear cells, to drug induced lupus disease in hepatitis C or cancer patients treated with recombinant IFN-a. In addition, mouse models of lupus in which the IFNR is deleted fail to develop disease manifestations. Thus, targetingIFN-a promises to be therapeuticallyefficacious for SLE.

Key Words: dendritic cells • gene expression profiling • IFN neutralizing antibodies • SLE • type I interferons

Lupus, Vol. 13, No. 5, 348-352 (2004)
DOI: 10.1191/0961203304lu1025oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M Petri, S Singh, H Tesfasyone, R Dedrick, K Fry, P. Lal, G Williams, J. Bauer, P. Gregersen, T. Behrens, et al. Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus Lupus, October 1, 2009; 18(11): 980 - 989. [Abstract] [PDF]

				S. A. Samarajiwa, S. Forster, K. Auchettl, and P. J. Hertzog INTERFEROME: the database of interferon regulated genes Nucleic Acids Res., January 1, 2009; 37(suppl_1): D852 - D857. [Abstract] [Full Text] [PDF]

				S. A. Greenberg Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications Neurology, November 20, 2007; 69(21): 2008 - 2019. [Abstract] [Full Text] [PDF]

				S. V. Navarra Immune therapy of lupus: what is on the horizon? Nephrol. Dial. Transplant., March 1, 2006; 21(3): 579 - 581. [Full Text] [PDF]

				S Vasoo and G R. Hughes Theory, targets and therapy in systemic lupus erythematosus Lupus, March 1, 2005; 14(3): 181 - 188. [Abstract] [PDF]

				T. Ishii, H. Onda, A. Tanigawa, S. Ohshima, H. Fujiwara, T. Mima, Y. Katada, H. Deguchi, M. Suemura, T. Miyake, et al. Isolation and Expression Profiling of Genes Upregulated in the Peripheral Blood Cells of Systemic Lupus Erythematosus Patients DNA Res, January 1, 2005; 12(6): 429 - 439. [Abstract] [Full Text] [PDF]