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T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective

Centre for Rheumatology, Royal Free and University College Medical School, London, UK, e.jury{at}ucl.ac.uk

P S Kabouridis

Bone and Joint Research Unit, Queen Mary’s School of Medicine and Dentistry, London, UK

In the last few years it has become clear that in cells of the immune system, specialized microdomains present in the plasma membrane, called lipid rafts, have been found to play a central role in regulating signalling by immune receptors. Recent studies have looked at whether lipid rafts may be connected to the abnormalities in signalling seen in T lymphocytes isolated from patients with systemic lupus erythematosus (SLE). These early findings show that in SLE T cells, the expression and protein composition of lipid rafts is different when compared with normal T cells. These results also demonstrate changes in the function and localization of critical signalling molecules such as the LCK tyrosine kinase and the CD45 tyrosine phosphatase.

Key Words: CD45 • intracellular signalling • LCK • lipid rafts • T lymphocytes

Lupus, Vol. 13, No. 6, 413-422 (2004)
DOI: 10.1191/0961203304lu1045rr


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