Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jury, E C
Right arrow Articles by Kabouridis, P S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jury, E C
Right arrow Articles by Kabouridis, P S
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 13, No. 6, 413-422 (2004)
DOI: 10.1191/0961203304lu1045rr

T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective

E C Jury

Centre for Rheumatology, Royal Free and University College Medical School, London, UK, e.jury{at}ucl.ac.uk

P S Kabouridis

Bone and Joint Research Unit, Queen Mary’s School of Medicine and Dentistry, London, UK

In the last few years it has become clear that in cells of the immune system, specialized microdomains present in the plasma membrane, called lipid rafts, have been found to play a central role in regulating signalling by immune receptors. Recent studies have looked at whether lipid rafts may be connected to the abnormalities in signalling seen in T lymphocytes isolated from patients with systemic lupus erythematosus (SLE). These early findings show that in SLE T cells, the expression and protein composition of lipid rafts is different when compared with normal T cells. These results also demonstrate changes in the function and localization of critical signalling molecules such as the LCK tyrosine kinase and the CD45 tyrosine phosphatase.

Key Words: CD45 • intracellular signalling • LCK • lipid rafts • T lymphocytes


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Jin, Y. Zhang, F. Yi, and P.-L. Li
Critical Role of Lipid Raft Redox Signaling Platforms in Endostatin-Induced Coronary Endothelial Dysfunction
Arterioscler. Thromb. Vasc. Biol., March 1, 2008; 28(3): 485 - 490.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. C. Jury, J. Eldridge, D. A. Isenberg, and P. S. Kabouridis
Agrin Signalling Contributes to Cell Activation and Is Overexpressed in T Lymphocytes from Lupus Patients
J. Immunol., December 1, 2007; 179(11): 7975 - 7983.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Nicolaou, P. Szigligeti, L. Neumeier, S. Molleran Lee, H. J. Duncan, S. K. Kant, A. B. Mongey, A. H. Filipovich, and L. Conforti
Altered Dynamics of Kv1.3 Channel Compartmentalization in the Immunological Synapse in Systemic Lupus Erythematosus
J. Immunol., July 1, 2007; 179(1): 346 - 356.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. C. Jury, D. A. Isenberg, C. Mauri, and M. R. Ehrenstein
Atorvastatin Restores Lck Expression and Lipid Raft-Associated Signaling in T Cells from Patients with Systemic Lupus Erythematosus
J. Immunol., November 15, 2006; 177(10): 7416 - 7422.
[Abstract] [Full Text] [PDF]