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Lupus, Vol. 13, No. 6, 463-468 (2004)
DOI: 10.1191/0961203304lu1049oa

Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus

S Fineschi

IRCCS Istituto Auxologico Italiano, Milan, Italy

M O Borghi

IRCCS Istituto Auxologico Italiano, Milan, Italy, Department of Internal Medicine, University of Milan, Milan, Italy

P Riboldi

IRCCS Istituto Auxologico Italiano, Milan, Italy, Department of Internal Medicine, University of Milan, Milan, Italy

M Gariglio

Department of Medical Sciences, University of Eastern Piedmont, Novara, Italy

C Buzio

Department of Clinical Medicine, Nephrology and Health Science, University of Parma, Parma, Italy

S Landolfo

Department of Public Health and Microbiology, University of Turin, Turin, Italy

L Cebecauer

National Institute for Rheumatic Diseases, Piestany, Slovak Republik

A Tuchynova

National Institute for Rheumatic Diseases, Piestany, Slovak Republik

J Rovensky

National Institute for Rheumatic Diseases, Piestany, Slovak Republik

P L Meroni

IRCCS Istituto Auxologico Italiano, Milan, Italy, Department of Internal Medicine, University of Milan, Milan, Italy, pierluigi.meroni{at}unimi.it

Antibodies (Abs) against the structure specific recognition protein 1 (SSRP1) were reported in a small systemic lupus erythematosus (SLE) series but not in other systemic autoimmune diseases. The aim of the study was to confirm the selective presence of anti-SSRP1 Abs in a larger SLE series and to evaluate their relationship with disease activity and other immune markers. Anti-SSRP1 Abs were investigated by a ‘home made’ ELISA in: 120 SLE, 65 rheumatoid arthritis (RA), 51 systemic sclerosis (SSc), 23 Churg-Strauss syndrome (CSS) and 40 idiopathic autoimmune urticaria (IAU) patients and 190 healthy controls. Sera from MRL lpr/lpr and Balb-c mice were also tested. Anti-SSRP1 Abs were detected in 43 SLE (35.8%), nine SSc (17.6%), eight RA (12.3%), six IAU (15%), three CSS (13%) patients and five healthy controls (2.6%). Antibody prevalence and titers were significantly higher in SLE patients than in sera from both normal and disease controls. Anti-SSRP1 Ab activity was also detected in sera from MRL lpr/lpr but not Balb-c mice. The antibodies did not correlate with the disease activity evaluated as the ECLAM index score and were more prevalent in patients without renal involvement. No correlation was found with other serum autoantibodies. Our results confirm that anti-SSRP1 Abs are associated with but not specific for the lupus disease.

Key Words: autoantibodies • SSRP1 • systemic lupus erythematosus


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