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Lupus
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Nephrogenic fibrosing dermopathy in two patients with systemic lupus erythematosus

G Obermoser

Department of Dermatology, University Hospital of Innsbruck, Innsbruck, Austria, gerlinde.obermoser{at}uibk.ac.at

M Emberger

Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria

M Wieser

Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria

B Zelger

Department of Dermatology, University Hospital of Innsbruck, Innsbruck, Austria

Nephrogenic fibrosing dermopathy (NFD) is a novel fibrosing disorder of the skin with characteristic histopathology. It affects patients with impaired renal function and appears to be independent from the type of kidney disease. Its aetiopathology is unknown and presently no standard therapy exists. We report a patient with systemic lupus erythematosus (SLE) and glomerulonephritis who developed diffuse indurated erythematous plaques covering nearly the entire legs and trunk. She had never received dialysis. The second patient suffered from SLE and antiphospholipid syndrome related thrombotic glomerulopathy. After 10 weeks of haemodialysis she developed the same skin condition. To the best of our knowledge, these are the first reports of NFD occurring in patients with SLE.

Key Words: nephrogenic fibrosing dermopathy • scleromyxoedema-like • SLE

Lupus, Vol. 13, No. 8, 609-612 (2004)
DOI: 10.1191/0961203304lu1069cr
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