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Antiphosphatidylserine antibodies and reproductive failure

Internal Medicine B and The Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel

Y Shoenfeld

Incumbent of the Laura Schwartz-Kipp Chair for Autoimmunity, Tel Aviv University, Israel, shoenfel{at}post.tau.ac.il

Some cases of reproductive failure with autoimmune background are characterized by the involvement of autoantibodies. This occurs mainly in patients having systemic lupus erythematosus or antiphospholipid syndrome. The autoantibodies associated with reproductive failure include: a) antibodies which directly bind phospholipid (e.g., cardiolipin, phosphatidylserine, phosphatidylethanolamine); b) antiphospholipid Abs which bind the phospholipid via phospholipid-binding glycoproteins such as b2glycoprotein-I, annexin V and prothrombin; c) autoantibodies directed to laminin-I, actin, thromboplastin, the corpus luteum, prolactin, poly (ADP-ribose), thyroglobulin and mitochondrial antibodies of the M5 type. This paper will focus on the association of antiphosphatidylserine autoantibodies and reproductive failure. Future studies are likely to help to identify peptides resembling the epitope specificities associated with the specific clinical manifestations.

Key Words: anti-annexine • anti-beta-2-glycoprotein • anti-prothrombin • antiphospholipid syndrome • apoptosis • autoimmunity • fetal loss

Lupus, Vol. 13, No. 9, 661-665 (2004)
DOI: 10.1191/0961203304lu1088oa


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				Y Shoenfeld and M Blank Autoantibodies associated with reproductive failure Lupus, September 1, 2004; 13(9): 643 - 648. [Abstract] [PDF]