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European register of babies born to mothers with antiphospholipid syndrome
M-C Boffa
Department of Internal Medicine, Hôpital de la Pitié, Paris, France, marie-claire.boffa{at}psl.ap-hop-paris.fr
M-H Aurousseau
Department of Hematology, Hôpital Jean Verdier, Bondy, France
E Lachassinne
Department of Pediatrics, Hôpital Jean Verdier, Bondy, France
H Dauphin
Department of Obstetrics and Gynecology, Hôpital Jean Verdier, Bondy, France
O Fain
Department of Internal Medicine, Hôpital Jean Verdier, Bondy, France
P Le Toumelin
Department of Epidemiology, Biobigny, UPRES EA 3409, France
M Uzan
Department of Obstetrics and Gynecology, Hôpital Jean Verdier, Bondy, France
J-C Piette
Department of Internal Medicine, Hôpital de la Pitié, Paris, France
S Derenne
CHU Hôtel-Dieu, Nantes, France
C Boinot
CHU La Milétrie, Poitiers, France
T Avcin
University Childrens Hospital Ljubljana, Slovenia
M Motta
Spedali Civili di Brescia, Brescia, Italy
D Faden
Spedali Civili di Brescia, Brescia, Italy
A Tincani
Spedali Civili di Brescia, Brescia, Italy
This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers clinical pattern of antiphospholipid syndrome (APS), course and outcome of pregnancy, treatment and immunological status. For the babies, clinical and immunological examinations are performed at birth; neuro-developmental conditions followed up to five years. A re-evaluation of lupus anticoagulant (LA), anticardiolipin (ACL) or other antibodies will be done if they are positive at birth to follow their kinetics. A descriptive and a case control study of babies with versus without APL at birth will be possible after the inclusion of 300 cases.
Key Words: anticardiolipin antibodies antiphospholipid antibodies babies development of babies infants lupus anticoagulant neonates obstetrical complications prematurity
Lupus, Vol. 13, No. 9,
713-717 (2004)
DOI: 10.1191/0961203304lu1089oa

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