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European register of babies born to mothers with antiphospholipid syndrome

Department of Internal Medicine, Hôpital de la Pitié, Paris, France, marie-claire.boffa{at}psl.ap-hop-paris.fr

M-H Aurousseau

Department of Hematology, Hôpital Jean Verdier, Bondy, France

E Lachassinne

Department of Pediatrics, Hôpital Jean Verdier, Bondy, France

H Dauphin

Department of Obstetrics and Gynecology, Hôpital Jean Verdier, Bondy, France

O Fain

Department of Internal Medicine, Hôpital Jean Verdier, Bondy, France

P Le Toumelin

Department of Epidemiology, Biobigny, UPRES EA 3409, France

M Uzan

Department of Obstetrics and Gynecology, Hôpital Jean Verdier, Bondy, France

J-C Piette

Department of Internal Medicine, Hôpital de la Pitié, Paris, France

S Derenne

CHU Hôtel-Dieu, Nantes, France

C Boinot

CHU La Milétrie, Poitiers, France

T Avcin

University Children’s Hospital Ljubljana, Slovenia

M Motta

Spedali Civili di Brescia, Brescia, Italy

D Faden

Spedali Civili di Brescia, Brescia, Italy

A Tincani

Spedali Civili di Brescia, Brescia, Italy

This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers’ clinical pattern of antiphospholipid syndrome (APS), course and outcome of pregnancy, treatment and immunological status. For the babies, clinical and immunological examinations are performed at birth; neuro-developmental conditions followed up to five years. A re-evaluation of lupus anticoagulant (LA), anticardiolipin (ACL) or other antibodies will be done if they are positive at birth to follow their kinetics. A descriptive and a case control study of babies with versus without APL at birth will be possible after the inclusion of 300 cases.

Key Words: anticardiolipin antibodies • antiphospholipid antibodies • babies • development of babies • infants • lupus anticoagulant • neonates • obstetrical complications • prematurity

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