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Lupus, Vol. 13, No. 9, 731-735 (2004)
DOI: 10.1191/0961203304lu2011oa

IVIG in APS pregnancy

G Triolo

Sezione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy, triolog{at}tiscalinet.it

A Ferrante

Sezione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

A Accardo-Palumbo

Sezione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

F Ciccia

Sezione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

M Cadelo

Sezione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

A Castelli

Dipartimento di Ostetricia e Ginecologia, University of Palermo, Palermo, Italy

A Perino

Dipartimento di Ostetricia e Ginecologia, University of Palermo, Palermo, Italy

G Licata

Sezione di Medicina Interna, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy

For more than two decades, the intravenous administration of high doses of IgG pooled from the plasma of healthy donors (immune globulin therapy, also known as ‘IVIG’) has benefited patients with a variety of autoimmune disorders. A potential therapeutic role of IVIG in the prevention of thrombosis and of miscarriages in antiphospholipid syndrome (APS) has been postulated. Multicenter randomized controlled trials attempted to define the role of IVIG in preventing pregnancy complications in APS indicate that simple anticoagulation could not be completely satisfactory, and certain patient subgroups might take advantage of IVIG therapy alone or in combination with heparin.

Key Words: APS • IVIG • pregnancy • recurrent fetal loss


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