This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Aringer, M Articles by Smolen, J S Search for Related Content PubMed PubMed Citation Articles by Aringer, M Articles by Smolen, J S Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?

Cytokine expression in lupus kidneys

Department of Rheumatology, Medical University of Vienna, Vienna, Austria

J S Smolen

Department of Rheumatology, Medical University of Vienna, Vienna, Austria, martin.aringer{at}meduniwien.ac.at

Although far from complete, the picture of cytokines present in systemic lupus erythematosus (SLE) glomerulonephritis is already complex. Proinflammatory cytokines, such as TNF, IL-6, IL-1, and IL-18 are upregulated, as are both Th1 and Th2 cytokines, with different implications. In many instances, the local effects may be different from the systemic immunoregulatory ones. For some proinflammatory cytokines, and TNF in particular, the local proinflammatory ones may be more relevant to the disease. This may help solve discrepancies between different murine models of the disease and provide a better rationale for targeting certain cytokines in human SLE.

Key Words: fibrosis • glomerulonephritis • inflammation • lupus • renal cytokines

Lupus, Vol. 14, No. 1, 13-18 (2005)
DOI: 10.1191/0961203305lu2053oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. Pflegerl, P. Vesely, B. Hantusch, M. Schlederer, R. Zenz, E. Janig, G. Steiner, A. Meixner, P. Petzelbauer, P. Wolf, et al. Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling PNAS, December 1, 2009; 106(48): 20423 - 20428. [Abstract] [Full Text] [PDF]

				B. H. Rovin and X. Zhang Biomarkers for Lupus Nephritis: The Quest Continues Clin. J. Am. Soc. Nephrol., November 1, 2009; 4(11): 1858 - 1865. [Abstract] [Full Text] [PDF]

				M. Aringer, F. Houssiau, C. Gordon, W. B. Graninger, R. E. Voll, E. Rath, G. Steiner, and J. S. Smolen Adverse events and efficacy of TNF-{alpha} blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients Rheumatology, November 1, 2009; 48(11): 1451 - 1454. [Abstract] [Full Text] [PDF]

				B. H. Rovin, A. M. McKinley, and D. J. Birmingham Can We Personalize Treatment for Kidney Diseases? Clin. J. Am. Soc. Nephrol., October 1, 2009; 4(10): 1670 - 1676. [Abstract] [Full Text] [PDF]

				L Zhu, X Yang, Y Ji, W Chen, W Guan, S. Zhou, and X Yu Up-regulated renal expression of TNF-{alpha} signalling adapter proteins in lupus glomerulonephritis Lupus, February 1, 2009; 18(2): 116 - 127. [Abstract] [PDF]

				M Aringer and J. Smolen TNF inhibition in SLE: where do we stand? Lupus, January 1, 2009; 18(1): 5 - 8. [PDF]

				H.-C. Chuang, J.-M. Wang, W.-C. Hsieh, Y. Chang, and I.-J. Su Up-Regulation of Activating Transcription Factor-5 Suppresses SAP Expression to Activate T Cells in Hemophagocytic Syndrome Associated with Epstein-Barr Virus Infection and Immune Disorders Am. J. Pathol., November 1, 2008; 173(5): 1397 - 1405. [Abstract] [Full Text] [PDF]

				Y. Hong, T. Wang, C. Huang, W. Cheng, and B. Lin Soy isoflavones supplementation alleviates disease severity in autoimmune-prone MRL-lpr/lpr mice Lupus, September 1, 2008; 17(9): 814 - 821. [Abstract] [PDF]

				T.-C. Hsu, S.-Y. Chiang, C.-Y. Huang, G. J. Tsay, C.-W. Yang, C.-N. Huang, and B.-S. Tzang Beneficial Effects of Treatment with Transglutaminase Inhibitor Cystamine on Macrophage Response in NZB/W F1 Mice Exp Biol Med, February 1, 2007; 232(2): 195 - 203. [Abstract] [Full Text] [PDF]

				M. J. Ryan and G. R. McLemore Jr. Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R736 - R742. [Abstract] [Full Text] [PDF]

				M DeBandt Lessons for lupus from tumour necrosis factor blockade Lupus, November 1, 2006; 15(11): 762 - 767. [Abstract] [PDF]

				S. V. Navarra Immune therapy of lupus: what is on the horizon? Nephrol. Dial. Transplant., March 1, 2006; 21(3): 579 - 581. [Full Text] [PDF]