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Lupus
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Genetics of lupus nephritis

B R Lauwerys

Service de Rhumatologie, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium, Bernard.Lauwerys{at}ruma.ucl.ac.be

E K Wakeland

Center for Immunology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA

Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcgRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. In mice, the generation of congenic mice, bearing in a normal genetic background one single disease-associated locus, greatly improved our understanding of the mechanisms mediating the genetic contribution to the disease. In the future, the identification of disease-associated genes will open new perspectives for the development of more targeted therapies of lupus nephritis.

Key Words: congenic mice • genetics • lupus • mouse models • SLE • susceptibility genes

Lupus, Vol. 14, No. 1, 2-12 (2005)
DOI: 10.1191/0961203305lu2052oa
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