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Lupus, Vol. 14, No. 1, 77-82 (2005)
DOI: 10.1191/0961203305lu2064oa

Novel therapies in lupus nephritis

H Tahir

Department of Medicine, University College London, Centre for Rheumatology, London, UK

D A Isenberg

Department of Medicine, University College London, Centre for Rheumatology, London, UK, d.isenberg{at}ucl.ac.uk

Renal disease continues to cause major morbidity and some mortality for around 30-40% of patients with systemic lupus erythematosus (SLE). Although the combinations of prednisolone and azathioprine or prednisolone and cyclophosphamide have been beneficial to many patients with SLE, they are not always effective and have significant side effects. It is very encouraging that new immunosuppressive drugs such as mycophenolate mofetil and more targeted therapies e.g., anti-CD20 are coming rapidly to larger scale clinical trials. The treatment of lupus nephritis is set to change quite rapidly in the next decade. In this review we highlight the likely major therapeutic advances.

Key Words: B cell depletion • cytokines • lupus nephritis • mycophenolate mofetil • systemic lupus erythematosus


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