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Lupus nephritis in children

Nephrology Unit, University of Genoa, Istituto G. Gaslini, Genoa, Italy

A Martini

Department of Paediatrics, University of Genoa, Istituto G. Gaslini, Genoa, Italy, albertomartini{at}ospedalegaslini.ge.it

In systemic lupus erythematosus renal involvement is more frequent in children than in adults. Overall, 60-80% of children with systemic lupus erythematosus have urinary or renal function abnormalities early in the disease course. In 90% of patients, renal disease occurs within two years from disease onset. Clinically significant renal involvement ranges from asymptomatic urinary findings to nephrotic syndrome and renal failure. Long-term prognosis is similar to that observed in adults. Treatment aspects that are peculiar to children include drug side-effects, such as growth inhibition induced by steroids, the need to consider morbidity-related issues with respect to the very long life expectancy of patients and the problems related to the impact of disease in adolescents. The recent availability of a childhood SLE definition of improvement and the presence of large international paediatric rheumatology networks should, in the future, facilitate the implementation of controlled clinical trials devoted to paediatric SLE.

Key Words: children • damage • juvenile systemic lupus erythematosus • nephritis • outcome

Lupus, Vol. 14, No. 1, 83-88 (2005)
DOI: 10.1191/0961203305lu2065oa


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