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Lupus
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Mast cells, TGF-ß1 and myofibroblasts expression in lupus nephritis outcome

R Cuan Ravinal

Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

R S Costa

Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil, rscosta{at}fmrp.usp.br

T M Coimbra

Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

M Dantas

Division of Nephrology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

M A dos Reis

Department of General Pathology, Faculty of Medicine of Triângulo Mineiro, Uberaba, Brazil

Renal biopsies of 69 patients with lupus nephritis were studied according to the WHO classification. The aim of the present study was to correlate the interstitial tryptase-positive mast cells with the interstitial TGF-ß1 and {alpha}-SM actin expression and clinical outcome of lupus nephritis, and identify the pathological role of the interstitial tryptase-positive mast cells in lupus nephritis. The mean follow-up time was 70.7 ± 54.4 months. Eight patients were grouped as WHO class II lupus nephritis, 15 patients as class III, 28 patients as class IV and 18 patients as class V. Interstitial tryptase-positive mast cells were not correlated with clinical outcome and interstitial TGF-ß1 expression in lupus nephritis. Interstitial tryptase-positive mast cells were correlated with tubulo-interstitial {alpha}-SM actin expression for WHO class V lupus nephritis, but not to the other classes. In conclusion, in spite of interstitial tryptase-positive mast cells being related to renal interstitial fibrosis process, their expression according to the clinical outcome of lupus nephritis was not significant.

Key Words: {alpha}-SM actin • lupus nephritis • mast cells • renal fibrosis • TGF-ß1

Lupus, Vol. 14, No. 10, 814-821 (2005)
DOI: 10.1191/0961203305lu2188oa
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This article has been cited by other articles:


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S. R. Holdsworth and S. A. Summers
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J. Am. Soc. Nephrol., December 1, 2008; 19(12): 2254 - 2261.
[Abstract] [Full Text] [PDF]


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