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High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine, ekarlson{at}partners.org

K H Costenbader

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, Massachusetts General Hospital, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

T E McAlindon

New England Medical Center, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

E M Massarotti

New England Medical Center, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

L M Fitzgerald

Beth Israel Deaconess Medical Center, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

R Jajoo

New England Medical Center, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

E Husni

Beth Israel Deaconess Medical Center, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

E A Wright

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

H Pankey

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

P A Fraser

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Robert B. Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Department of Medicine

The Connective Tissue Disease Screening Questionnaire (CSQ), developed to screen populations for SLE and other CTDs, has been validated in a predominantly Caucasian population with hospital-based controls. We aimed to test the performance characteristics of the CSQ in an urban, predominantly African-American population. The CSQ was administered by interview to women recruited for a study of environmental risk factors and SLE, including 99 cases with SLE validated by medical record review and 202 healthy controls recruited from the community. Overall, 88% of subjects had African heritage, 6% were Hispanic and 4% were non-Hispanic Caucasian. Controls were more likely to report African heritage than cases (91% versus 82%, P < 0.001). Sensitivity for detecting SLE was 88% and specificity was 91%. In this study, where the prevalence of SLE was 33%, predictive value of a positive CSQ was 82% and predictive value of a negative CSQ was 94%. The CSQ has slightly lower sensitivity but greater specificity for SLE in an urban, predominantly African-American population with community-based controls compared with a Caucasian population with hospital-based controls. These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE.

Key Words: African-American • connective tissue disease • lupus • screening • sensitivity

Lupus, Vol. 14, No. 10, 832-836 (2005)
DOI: 10.1191/0961203305lu2227oa


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