This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Dasgupta, N Articles by Fine, D M Search for Related Content PubMed PubMed Citation Articles by Dasgupta, N Articles by Fine, D M Social Bookmarking                         What's this?

Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

A C Gelber

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

F Racke

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

D M Fine

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA, dfine1{at}jhmi.edu

Lymphomas, both within and outside the central nervous system, are uncommon among patients with systemic lupus erythematosus (SLE). We describe a 58-year old Korean woman with SLE who presented with acute headache and confusion in the setting of prednisone and mycophenolate mofetil (MMF) therapy used to treat focal proliferative and membranous lupus nephritis. Three-dimensional brain magnetic resonance imaging (MRI) showed two peripherally (‘ring’) enhancing lesions within the basal ganglia, bilaterally, with associated mass effect and subfalcine herniation. A brain biopsy revealed an Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma. This is the first description of CNS lymphoma in a patient treated with MMF for lupus nephritis. While intracerebral lymphoma in the immunocompromised patient with lupus is rare, this disorder should be considered in the differential diagnosis of new-onset neurological symptoms among such patients.

Key Words: central nervous system lymphoma • immunosuppression • lupus nephritis • mycophenolate mofetil • systemic lupus erythematosus

Lupus, Vol. 14, No. 11, 910-913 (2005)
DOI: 10.1191/0961203303lu2179cr


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. Jacob, M. Matiello, B. G. Weinshenker, D. M. Wingerchuk, C. Lucchinetti, E. Shuster, J. Carter, B. M. Keegan, O. H. Kantarci, and S. J. Pittock Treatment of Neuromyelitis Optica With Mycophenolate Mofetil: Retrospective Analysis of 24 Patients Arch Neurol, September 1, 2009; 66(9): 1128 - 1133. [Abstract] [Full Text] [PDF]

				F Falcini, S Capannini, G Martini, F La Torre, A Vitale, F Mangiantini, F Nacci, M. Cerinic, R Cimaz, and F Zulian Mycophenolate mofetil for the treatment of juvenile onset SLE: a multicenter study Lupus, February 1, 2009; 18(2): 139 - 143. [Abstract] [PDF]

				N. Kumar, P. Sandroni, D. P. Steensma, H. S. Luthra, and T. M. Habermann POLYRADICULOPATHY DUE TO METHOTREXATE-INDUCED EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISORDER Neurology, November 11, 2008; 71(20): 1644 - 1645. [Full Text] [PDF]

				A. J. Gerbino, C. H. Goss, and J. A. Molitor Effect of Mycophenolate Mofetil on Pulmonary Function in Scleroderma-Associated Interstitial Lung Disease* Chest, February 1, 2008; 133(2): 455 - 460. [Abstract] [Full Text] [PDF]

				B. P. O'Neill, S. Vernino, A. Dogan, and C. Giannini EBV-associated lymphoproliferative disorder of CNS associated with the use of mycophenolate mofetil Neuro-oncol, July 1, 2007; 9(3): 364 - 369. [Abstract] [Full Text] [PDF]

				P F Finelli, K Naik, J A DiGiuseppe, and A Prasad Primary lymphoma of CNS, mycophenolate mofetil and lupus Lupus, December 1, 2006; 15(12): 886 - 888. [Abstract] [PDF]

				A Doria, L Iaccarino, S Arienti, M E Rampudda, M G Canova, R Rondinone, and S Todesco Mycophenolate mofetil and systemic lupus erythematosus Lupus, November 1, 2006; 15(11_suppl): 44 - 54. [Abstract] [PDF]

				A Sinclair and R Baildon Mycophenolate mofetil: an overview Lupus, November 1, 2006; 15(11_suppl): 70 - 77. [PDF]