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Lupus
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What's this?

Hyperacute renal failure as the initial presentation of systemic lupus erythematosus

O Arbel

Department of Medicine, Hadassah University Hospital, Jerusalem, Israel

G Pizov

Department of Pathology, Hadassah University Hospital, Jerusalem, Israel

A Ben-Yehuda

Department of Medicine, Hadassah University Hospital, Jerusalem, Israel

A Rubinow

Department of Medicine, Hadassah University Hospital, Jerusalem, Israel

Y Naparstek

Department of Medicine, Hadassah University Hospital, Jerusalem, Israel

H Amital

Department of Medicine, Hadassah University Hospital, Jerusalem, Israel, amitalh{at}netvision.net.il

SLE nephritis is usually a slow process that may lead to renal failure many years after its first presentation. Success of different therapeutic modalities in preventing renal failure is therefore evaluated and compared only after many years of treatment. Lately, this conservative philosophy has been challenged with the acknowledgment of collapsing glomerulopathy (CG), a recent recognized clinical-pathological entity, characterized by rapidly progressive renal failure. Despite this ominous description we present an unusual case of a patient who presented with systemic lupus erythematosus (SLE) and clinical and pathological findings of CG, who completely remitted several weeks after commencing immunosuppressive therapy with intravenous cyclophosphamide and prednisolone.

Key Words: acute renal failure • collapsing glomerulopathy • cyclophosphamide • nephritic syndrome • systemic lupus nephritis

Lupus, Vol. 14, No. 4, 331-333 (2005)
DOI: 10.1191/0961203305lu2070cr
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This article has been cited by other articles:


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