This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Eny, K M Articles by Bae, S-C Search for Related Content PubMed PubMed Citation Articles by Eny, K M Articles by Bae, S-C Social Bookmarking                         What's this?

Catalase and PPARg2 genotype and risk of systemic lupus erythematosus in Koreans

Department of Nutritional Sciences, University of Toronto, Toronto, Canada

A El-Sohemy

Department of Nutritional Sciences, University of Toronto, Toronto, Canada

M C Cornelis

Department of Nutritional Sciences, University of Toronto, Toronto, Canada

Y-K Sung

Department of Internal Medicine, Division of Rheumatology, the Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea

S-C Bae

Department of Internal Medicine, Division of Rheumatology, the Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea, scbae{at}hanyang.ac.kr

Catalase (CAT) and peroxisome proliferator activated receptor-g2 (PPARg2) are important regulators of oxidative stress and inflammation, which may contribute to the development of systemic lupus erythematosus (SLE). The objective of this study was to investigate the effects of genetic polymorphisms of CAT and PPARg2 on risk and severity of SLE in a Korean population. DNA was isolated from blood samples collected from 345 patients with SLE and 400 controls. Genotyping for the 2262C!T polymorphism of CAT and the Pro12Ala polymorphism of PPARg2 were performed by PCR-RFLP analysis. The severity of SLE was assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). No association was observed between genotypes for any of the clinical manifestations of SLE. CAT and PPARg2 genotypes were not associated with either risk or severity of SLE. For subjects who were carriers of the high activity Tallele for CATand have the Pro/Pro genotype for PPARg2, the odds ratio (95% confidence interval) for risk of SLE was 0.45 (0.23-1.08). Our results suggest that genetic polymorphisms of CAT and PPARg2 do not play a significant role in the development of SLE in a Korean population. A possible protective effect of a combined genotype warrants further investigation.

Key Words: catalase • genotype • oxidative stress • PPARg • systemic lupus erythematosus

Lupus, Vol. 14, No. 5, 351-355 (2005)
DOI: 10.1191/0961203305lu2091oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. J. Ryan Young Investigator Award Lecture of the APS Water and Electrolyte Homeostasis Section, 2008: The pathophysiology of hypertension in systemic lupus erythematosus Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1258 - R1267. [Abstract] [Full Text] [PDF]