This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sprovieri, S R. Articles by Sens, Y A. Search for Related Content PubMed PubMed Citation Articles by Sprovieri, S R. Articles by Sens, Y A. Social Bookmarking                         What's this?

Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy

Department of Internal Medicine, Faculty of Medical Sciences, Santa Casa de São Paulo, Brazil, luvieri{at}uol.com.br

Y AS Sens

Department of Internal Medicine, Faculty of Medical Sciences, Santa Casa de São Paulo, Brazil

Genetic polymorphisms of the renin-angiotensin system (RAS) has been associated with cardiovascular events and the progression of nephropathy in several diseases. The objective of this study was to evaluate a possible association of the genetic polymorphisms of RAS with the development and/or progression of lupus nephritis in a Brazilian population. Seventy-five SLE patients with lupus nephropathy (LN group) were compared to 72 SLE patients without LN (SLE group) and 65 healthy individuals (CONTROL group), of sex and ethnic matched, in a Brazilian population sample. Mean global follow-up was 9 + 6 years for lupus without nephropathy and 11 + 7 years for lupus nephropathy. Following the extraction of genomic DNA from the leukocytes in the peripheral blood, angiotensin converting enzyme (ACE I/D), angiotensinogen (AGT M²³⁵T) and angiotensin II type 1 receptor (AGTR1 A¹¹⁶⁶C) genotypes were determined by the polymerase chain reaction.

No significant difference of ACE, AGT and AGTR1 genotypes distribution between groups was observed in this study. There was no significant association between the variables of the RAS genotypes and the presence of hypertension in SLE. However, an increased frequency of DD genotype (ACE I/D) was observed in SLE patients with LN who progressed to CRF compared to healthy controls (DD 60%, DI 26.7%, II 13.3% versus 27.7%, 60% and 12.3%, respectively; x2 = 6.299, P = 0.0429). In the population studied, there was no influence of the RAS genetic polymorphisms in the development of lupus nephropathy, but the progression to CRF was associated with ACE DD polymorphism.

Key Words: Brazil • genetic polymorphism • nephropathy • renin-angiotensin system • systemic lupus erythematosus

Lupus, Vol. 14, No. 5, 356-362 (2005)
DOI: 10.1191/0961203305lu2093oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				V Teplitsky, Y Shoenfeld, and A Tanay The renin-angiotensin system in lupus: physiology, genes and practice, in animals and humans Lupus, June 1, 2006; 15(6): 319 - 325. [Abstract] [PDF]