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Anti-glutamic acid decarboxylase antibodies in a patient with systemic lupus erythematosus and fibromyalgia symptoms

Divisions of Rheumatology and Respirology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada, r.gjevre{at}usask.ca

J A Gjevre

Divisions of Rheumatology and Respirology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada

We report the case of a 29-year old female nurse with a five-year history of systemic lupus erythematosus (SLE) involving multiple systems and on chronic prednisone therapy. This patient has a coexisting diagnosis of fibromyalgia fulfilling ACR criteria. A recent deterioration in her level of functioning in addition to a flare of her inflammatory disease led to further evaluation. During the course of investigation an anti-glutamic acid decarboxylase antibody was found to be present and significantly elevated. A therapeutic trial of baclofen did result in improvement of her subjective myalgias. We raise the possibility of an autoimmune contribution to myalgic symptoms in a portion of SLE patients.

Key Words: anti-GAD antibodies • fibromyalgia • GABA • myalgias • systemic lupus erythematosus

Lupus, Vol. 14, No. 6, 486-488 (2005)
DOI: 10.1191/0961203305lu2095cr


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