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High prevalence of vertebral deformity in premenopausal systemic lupus erythematosus patients

Division of Endocrinology, Universidade Federal de São Paulo, São Paulo, Brazil, Serviço de Endocrinologia da Universidade Federal do Paraná (SEMPR), Curitiba, Brazil, familiabborba{at}aol.com

P G Matos

Division of Radiology, Universidade Federal de São Paulo, São Paulo, Brazil

P R da Silva Viana

Division of Endocrinology, Universidade Federal de São Paulo, São Paulo, Brazil

A Fernandes

Division of Radiology, Universidade Federal de São Paulo, São Paulo, Brazil

E I Sato

Division of Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil

M Lazaretti-Castro

Division of Endocrinology, Universidade Federal de São Paulo, São Paulo, Brazil

In this paper we searched for vertebral deformities in a group of 70 premenopausal systemic lupus erythematosus (SLE) patients (31.8 ± 8.1 years old) and compared them to a matched control group of 22 healthy women (32.0 ± 8.9 years old). Patients and controls performed spine X-ray (XR) morphometry and lumbar spine and femoral neck bone mineral density (BMD). Clinical data was obtained by a questionnaire and charts review. Thoracic or lumbar spine fracture was observed in 15 (21.4%) SLE patients, while no deformities were found in the control group (P = 0.018). BMD was not different amongst SLE patients and controls and between SLE patients with or without deformities. Although BMD could not predict what patient have deformity, seven patients (46.6%) with deformity had a lumbar spine or femoral neck Z-score less than -1 SD [median = -0.59 (-3.72 to +0.88) and -0.20 (-4.05 to +1.87)] respectively. In addition, we found a negative correlation between number of fracture per patient and lumbar spine and femoral neck BMD (R = 0.58, P = 0.04 and R = 0.84, P = <0.0001 respectively). No significant correlation was found between number of deformities and clinical data. This is the first study to search for vertebral deformities in SLE patients and to demonstrate a high prevalence of deformities in a relative young SLE population. These findings bring up the necessity to look for spine deformities in this group of women regardless the BMD.

Key Words: BMD • corticosteroids • fracture • systemic lupus erythematosus • vertebral deformity

Lupus, Vol. 14, No. 7, 529-533 (2005)
DOI: 10.1191/0961203305lu2154oa


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