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Lupus, Vol. 14, No. 7, 554-556 (2005)
DOI: 10.1191/0961203305lu2099cr

Relapse with transformation of lupus nephritis in a transplant kidney

M Thomas

Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

J Blennerhassett

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

R Walker

Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand, rob.walker{at}stonebow.otago.ac.nz

Lupus nephritis is a constellation of different renal histologies, characterized by an immune complex mediated glomerular disease. Histological transformation in lupus nephritis usually occurs from a mild mesangial proliferative glomerulonephritis to a more aggressive diffuse proliferative lesion. We present a case of relapsed systemic lupus erythematosus (SLE) in a renal transplant recipient in which there was a histological transformation from the original diffuse proliferative lupus nephritis in the native kidneys to a membranous lupus nephritis in the renal transplant.

Key Words: histocompatibility antigens • histological transformation • lupus nephritis • renal transplantation


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