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Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus

Department of Medicine and Care, University of Linköping, Jönköping Hospital, Sweden; Department of Clinical Physiology, Jönköping Hospital, S-551 85 Jönköping, Sweden; niklas.bjarnegard{at}lj.se

C Bengtsson

Department of Rheumatology, Lund University Hospital, Lund, Sweden

J Brodszki

Department of Women’s Health, Lund University Hospital, Lund, Sweden

G Sturfelt

O Nived

Department of Rheumatology, Lund University Hospital, Lund, Sweden

T Länne

Department of Medicine and Care, University of Linköping, Sweden

Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls.

Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3).

Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort.

Key Words: arteries • blood pressure • elasticity • pulse • SLE • women

Lupus, Vol. 15, No. 10, 644-650 (2006)
DOI: 10.1177/0961203306071402


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