This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sánchez, E Articles by Martín, J Search for Related Content PubMed PubMed Citation Articles by Sánchez, E Articles by Martín, J Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Medline Plus Health Information Lupus Social Bookmarking                   What's this?

Study of a functional polymorphism in thep53 gene in systemic lupus erythematosus: lack of replication in a Spanish population

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain

J M Sabio

Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain

J L Callejas

Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain

E de Ramón

Servicio de Medicina Interna, Hospital Carlos-Haya, Málaga, Spain

M de Haro

Hospital Universitario Virgen de la Victoria, Málaga, Spain

J Jiménez-Alonso

Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain

N Ortego-Centeno

Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain

J Sánchez-Román

Servicio de Medicina Interna, Hospital Virgen del Rocío, Sevilla, Spain

M A González-Gay

Servicio de Reumatología, Hospital Xeral-Calde, Lugo, Spain

M A López-Nevot

Servicio de Inmunología, Hospital Virgen de las Nieves, Granada, Spain

M F González-Escribano

Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain

J Martín

Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n 18100-Armilla (Granada), Spainmartin{at}ipb.csic.es

The aim of this study was to assess the possible association between the p53 suppressor gene codon 72 polymorphism and systemic lupus erythematosus (SLE). Our study population consisted of 513 SLE patients and 567 healthy controls. All the individuals were of Spanish Caucasian origin. Genotyping of the p53 codon 72 polymorphism was performed by allele-specific PCR. No statistically significant differences were observed between SLE patients and healthy controls when p53 codon 72 genotype and allele frequencies were compared. In addition, no evidence for association with clinical subfeatures of SLE was found. In conclusion, the p53 codon 72 polymorphism associated with SLE in a Korean population does not appear to play a major role in the susceptibility or severity of SLE in the Spanish population.

Key Words: polymorphism • systemic lupus erythematosus • p53gene • susceptibility • association

Lupus, Vol. 15, No. 10, 658-661 (2006)
DOI: 10.1177/0961203306070986


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K. Onel, D Huo, D Hastings, J Fryer-Biggs, M. Crow, and K Onel Lack of Association of the TP53 Arg72Pro SNP and the MDM2 SNP309 with systemic lupus erythematosus in Caucasian, African American, and Asian children and adults Lupus, January 1, 2009; 18(1): 61 - 66. [Abstract] [PDF]

				P. Piotrowski, M. Lianeri, M. Mostowska, M. Wudarski, H. Chwalinska-Sadowska, and P. Jagodzinski Contribution of polymorphism in codon 72 of p53 gene to systemic lupus erythematosus in Poland Lupus, February 1, 2008; 17(2): 148 - 151. [Abstract] [PDF]