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Lupus, Vol. 15, No. 11, 724-727 (2006)
DOI: 10.1177/0961203306071705

Ultraviolet light and cutaneous lupus

Marc Bijl

Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlandsm.bijl{at}int.umcg.nl

Cees GM Kallenberg

Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining the development of inflammation in lupus patients. We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions.

Key Words: lupus • UVB • apoptosis • autoantibodies


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