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Lupus, Vol. 15, No. 11 suppl, 55-58 (2006)
DOI: 10.1177/0961203306071669

Reviews

Antiphospholipid (Hughes) syndrome and atheroma

R J Davies

Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK

S R Sangle

Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK

M A Khamashta

Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK

D P D’Cruz

Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK, david.d'cruz{at}kcl.ac.uk

The antiphospholipid syndrome (APS) is a prothrombotic disorder characterised by recurrent thrombotic events and pregnancy morbidity in the context of autoantibodies against phospholipid binding proteins. There is increasing evidence that these autoantibodies are associated with accelerated atherosclerosis. The presence of stenotic lesions radiologically and abnormalities of the ankle-brachial index, flow-mediated dilatation and carotid abnormalities supports this view and this clinical evidence is reviewed.

Key Words: antiphospholipid syndrome • atheroma • ankle brachial index


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