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cAMP response element modulator expression in patients with systemic lupus erythematosus

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA, Section of Rheumatology, Washington Hospital Center, Washington, DC, USA

Y Wang

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA

Y-T Juang

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA

A Weinstein

Section of Rheumatology, Washington Hospital Center, Washington, DC, USA

G C Tsokos

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA, gtsokos{at}gmail.com

T cells from patients with systemic lupus erythematosus (SLE) have high levels of cAMP response element modulator (CREM)- which bind to the interleukin (IL-2) promoter and limit IL-2 production. In this case-controlled study, we show that CREM- mRNA levels were higher in T cells from patients with SLE than controls while CREB mRNA levels did not differ between the two groups. CREM- mRNA levels did not correlate with clinical characteristics, disease activity or treatment. Nevertheless, there was a trend for patients on high doses of corticosteroids to have low levels of CREM- mRNA. The discovery of specific non-toxic medications that block the expression of CREM- may prove useful in reversing the aberrant T cell function in SLE.

Key Words: corticosteroids • CREM • lupus • T cells • transcription factors

Lupus, Vol. 15, No. 12, 840-844 (2006)
DOI: 10.1177/0961203306069985


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