This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Micheloud, D Articles by López-Longo, F J Search for Related Content PubMed PubMed Citation Articles by Micheloud, D Articles by López-Longo, F J Social Bookmarking                         What's this?

Efficacy and safety of Etanercept, high-dose intravenous gammaglobulin and plasmapheresis combined therapy for lupus diffuse proliferative nephritis complicating pregnancy

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

L Nuño

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain

M Rodríguez-Mahou

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

S Sánchez-Ramón

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

M C Ortega

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain

A Aguarón

Obstretics and Gynecology Department, University General Hospital Gregorio Marañón, Madrid, Spain

E Junco

Nephrology Department, University General Hospital Gregorio Marañón, Madrid, Spain

J Carbone

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

E Fernández-Cruz

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

L Carreño

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain

F J López-Longo

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain, fjlopezlongo{at}hotmail.com

We report one case of pregnancy-onset severe diffuse proliferative nephritis in a patient with systemic lupus erythematosus (SLE), who was successfully treated with a combination of anti-tumour necrosis factor (TNF)-alpha, plasmapheresis and high-dose intravenous gammaglobulin. No flares were observed either in clinical symptoms or in laboratory examinations during pregnancy or after delivery. Her autoantibodies except fluorescent anti-nuclear antibodies were negative. We suggest that a combination of anti-TNF-alpha, plasmapheresis and high-dose intravenous gammaglobulin may be a safe and effective therapy for pregnant patients suffering severe lupus nephritis.

Key Words: systemic lupus erytematosus • pregnancy • etanercept • intravenous gammaglobulin and plasmapheresis.

Lupus, Vol. 15, No. 12, 881-885 (2006)
DOI: 10.1177/0961203306070970


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. Youssef and D. Kennedy Arthritis in pregnancy: the role and safety of biological agents Obstet Med, December 1, 2009; 2(4): 134 - 137. [Abstract] [Full Text] [PDF]

				M. C. Soh, H. H Hart, E. Bass, and L. Wilkinson Pregnancy complicating Wegener's granulomatosis Obstet Med, June 1, 2009; 2(2): 77 - 80. [Abstract] [Full Text] [PDF]

				C. A. Heyneman Systemic Lupus Erythematosus: A Therapeutic Update Journal of Pharmacy Practice, February 1, 2009; 22(1): 29 - 52. [Abstract] [PDF]

				M. Ostensen, M. Lockshin, A. Doria, G. Valesini, P. Meroni, C. Gordon, A. Brucato, and A. Tincani Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs Rheumatology, June 1, 2008; 47(suppl_3): iii28 - iii31. [Abstract] [Full Text] [PDF]