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Circulating levels of ß2-glycoprotein I in thrombotic disorders and in inflammation

Department of Biological Sciences, Dublin Institute of Technology, St James’s Hospital, Dublin

R Murphy

Department of Cardiology, St James’s Hospital, Dublin

B White

National Centre for Hereditary Coagulation Disorders, St James’s Hospital, Dublin

J Kelly

Department of Biological Sciences, Dublin Institute of Technology, St James’s Hospital, Dublin

C Feighery

Department of Immunology, St James’s Hospital, Dublin

R Doyle

Medicine for the Elderly, St James’s Hospital, Dublin

S Pittock

Department of Medicine, Beaumont Hospital, Dublin

J Moroney

Department of Medicine, Beaumont Hospital, Dublin

O Smith

Trinity Smurfit Institute of Genetics, Trinity College Dublin; Republic of Ireland

W Livingstone

Trinity Smurfit Institute of Genetics, Trinity College Dublin; Republic of Ireland

C Keenan

Trinity Smurfit Institute of Genetics, Trinity College Dublin; Republic of Ireland

J Jackson

Department of Immunology, St James’s Hospital, Dublin, john.jackson{at}tcd.ie

ß2₂-glycoprotein I (ß2GPI) is a plasma protein suspected to have a role in inhibition of thrombosis. This suspicion is reinforced by the observation that ß2GPI is the major target for autoantibodies in the antiphospholipid syndrome. However, little is known about its circulating levels in common thrombotic diseases or inflammation. We measured ß2GPI levels in 344 healthy controls, 58 normal pregnancies, 102 patients with non-haemorrhagic stroke, 121 patients with acute coronary syndrome and 200 patients with elevated C-reactive protein (CRP). In healthy individuals, we found a strong positive correlation between age and ß2GPI concentration (r = 0.274, P < 0.001) and that ß2GPI levels fall significantly after the eighth week of pregnancy (P = 0.002). We also found significantly reduced levels of ß2GPI in patients with stroke and in elderly patients with myocardial syndrome (P = 0.013 and 0.043). However, in neither group did ß2GPI levels change in the following six months, suggesting that the reduced levels were not a transient post-event phenomenon. In patients with inflammation, ß2GPI levels showed a significant negative correlation with CRP (r =-0.284, P < 0.001) and positively correlated with albumin and transferrin (r = 0.372 and 0.453, respectively with P < 0.001 for both). Furthermore, the largest reduction in ß2GPI levels occurred in patients with the highest CRP values (P < 0.001).

Key Words: acute coronary syndrome • ß2-glycoprotein I • inflammation • pregnancy • stroke

Lupus, Vol. 15, No. 2, 87-93 (2006)
DOI: 10.1191/0961203306lu2270oa


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