This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Barber, C E. Articles by Hanly, J G Search for Related Content PubMed PubMed Citation Articles by Barber, C E. Articles by Hanly, J G Social Bookmarking                   What's this?

Sustained remission of lupus nephritis

Division of Rheumatology, Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada

L Geldenhuys

Division of Anatomical Pathology, Department of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada

J G Hanly

Division of Rheumatology, Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada, john.hanly{at}cdha.nshealth.ca

The aim of this study was to describe the clinical course of patients with lupus nephritis (LN) who attain a sustained remission (SR) and identify predictors of SR. A retrospective study of patients with biopsy-proven LN were followed for up to 10 years. SR was defined as normal renal function, urine protein <0.5 g/day, and an inactive urine sediment without significant immunosuppressive maintenance therapy for no less than three years. Control patients had LN but did not fulfill the criteria for SR. Data was collected at diagnosis of LN (T₀), at onset of remission (T₁), and at final follow-up (T₂). A total of 35 patients were identified, 16 with a SR of LN and 19 controls, with a mean ± SD follow-up of 126.4 ± 8.5 months. Remission of LN was achieved following 37.7 ± 6.8 months of therapy. At diagnosis (T₀) the WHO classification of nephritis, activity and chronicity scores of renal biopsies were comparable in the two groups. At final follow-up (T₂), the mean estimated creatinine clearance for the SR group was significantly higher than in controls (P = 0.009) and disease activity (SLEDAI scores) was lower (P = 0.002). Cumulative damage (SDI scores) in the SR group did not increase after patients entered remission (P = 0.250), whereas the mean SDI score in the control group increased significantly (P = 0.014) even when renal variables were excluded (P = 0.016). Multivariate analysis revealed that female gender (P = 0.023), older age (P = 0.034), higher non-renal SLEDAI scores (P = 0.016) at the time of diagnosis of LN and absence of azathioprine (P = 0.010) were predictive of SR. It was concluded that remission of LN occurs in a substantial proportion of systemic lupus erythematosus (SLE) patients and may be sustained without maintenance immunosuppressive therapy. It is associated with a significantly slower accrual of both renal and non-renal damage over the ensuing seven years.

Key Words: damage • lupus nephritis • remission

Lupus, Vol. 15, No. 2, 94-101 (2006)
DOI: 10.1191/0961203306lu2271oa


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A Siso, M Ramos-Casals, A Bove, P Brito-Zeron, N Soria, S Munoz, A Testi, J Plaza, J Sentis, and A Coca Previous antimalarial therapy in patients diagnosed with lupus nephritis: Influence on outcomes and survival Lupus, April 1, 2008; 17(4): 281 - 288. [Abstract] [PDF]

				Y. E. Chen, S. M. Korbet, R. S. Katz, M. M. Schwartz, E. J. Lewis, and for the Collaborative Study Group Value of a Complete or Partial Remission in Severe Lupus Nephritis Clin. J. Am. Soc. Nephrol., January 1, 2008; 3(1): 46 - 53. [Abstract] [Full Text] [PDF]