SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Karim, M Y
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karim, M Y
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Lupus
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Immunodeficiency in the lupus clinic

M Y Karim

Frimley Park Hospital, Frimley, Surrey and Lupus Research Unit, St Thomas’ Hospital, London

Systemic lupus erythematous (SLE) and immunodeficiency are linked in various ways. For example, rare genetic complement deficiencies can pre-dispose to developing SLE, whilst some treatments for SLE can cause secondary immunodeficiencies. Various case reports describe SLE patients who have concomitant or later develop antibody deficiency, possibly related to immunosuppressive treatment, or possibly related to the lupus itself. Other components of the immune system, innate and adaptive may also be affected. Immunosuppressive treatment may also cause infections in the absence of defects on routine immunological testing. It is important for the clinician to be aware of the associations between SLE and immunodeficiency to ensure optimal investigation and management. This review focuses on aspects of humoral and cellular immunity, and their association with SLE.

Key Words: antibody • B-cell • B-lymphocyte • hypogammaglobulinaemia • immunodeficiency • lupus

Lupus, Vol. 15, No. 3, 127-131 (2006)
DOI: 10.1191/0961203306lu2282rr
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
C. Samarghitean, C. Ortutay, and M. Vihinen
Systematic Classification of Primary Immunodeficiencies Based on Clinical, Pathological, and Laboratory Parameters
J. Immunol., December 1, 2009; 183(11): 7569 - 7575.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
P. F. K. Yong, L. Aslam, M. Y. Karim, and M. A. Khamashta
Management of hypogammaglobulinaemia occurring in patients with systemic lupus erythematosus
Rheumatology, September 1, 2008; 47(9): 1400 - 1405.
[Abstract] [Full Text] [PDF]


Advertisement