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A case of minimal-change nephrotic syndrome in pediatric lupus erythematosus: just a coincidence?

Department of Pediatrics, National Cheng Kung University Medical Center and College of Medicine, Tainan, Taiwan

H-H Chou

Department of Pediatrics, National Cheng Kung University Medical Center and College of Medicine, Tainan, Taiwan

F-F Chen

Department of Pathology, National Cheng Kung University Medical Center and College of Medicine, Tainan, Taiwan

M-J Chen

Department of Nursing, Chung Hwa Institute of Technology, Tainan, Taiwan

Y-Y Chiou

Department of Pediatrics, National Cheng Kung University Medical Center and College of Medicine, Tainan, Taiwan, Institute of Clinical Medicine, National Cheng Kung University Medical Center and College of Medicine, Tainan, Taiwan, yuanyow{at}mail.ncku.edu.tw

A 14-year old girl with lupus erythematosus (LE) who initially showed as discoid lupus and followed with nephrotic syndrome one year later. Concomitant piroxicam and indomethacin were prescribed for her arthritis, which preceded two months before the onset of nephrotic syndrome. Histology from renal biopsy showed minimal-change nephrotic syndrome (MCNS). After continuous treatment for six months, nephrotic syndrome resolved completely and no signs of relapse were noted over 14 years of follow-up. For the children, it is rare to have both LE and MCNS simultaneously; sequela of nonsteroidal anti-inflammatory drugs also seldom results in nephrotic syndrome. Though their relationship is still not defined, the possibility of LE combined with MCNS must be differentiated in patients with lupus and severe proteinuria.

Key Words: children • lupus erythematosus • lupus nephritis • minimal change nephrotic syndrome • nonsteroidal anti-inflammatory drugs

Lupus, Vol. 15, No. 4, 244-247 (2006)
DOI: 10.1191/0961203306lu2285cr


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